Information About Breast, Endometrium and Ovarian Cancers
There are hundreds, if not thousands, of papers in peer-reviewed medical journals dating back to the mid 1980s relating to the causes and prevention of breast, cervical, ovarian, endometrial and corpus uterine cancers. Unfortunately, this information is generally not read by medical practitioners, specialists or health support organisations.
As Professor Michael Brown, one of the leading medical researchers of the 20th century, stated in a speech to students at an Academy of Achievement event in 2006:
Whilst Professor Brown, winner of the Nobel Prize in Physiology or Medicine in 1985, was referring to heart disease, the same applies to other “diseases of affluence“.
Sex Hormones and Cancer
There are many papers linking sex hormones to breast, endometrium and ovarian cancers as well as prostate cancer. Below is a very small selection.
Diet and Sex Hormones
Given that sex hormones are implicated in a number of cancers, how do we reduce the amount of sex hormones? Caldwell Esselstyn writes that in Japan in 1958 there were 18 deaths from prostate cancer and 137 in the year 1978. As their diet becomes more western, then their incidence of prostate cancer rises.
One simple way is to stop consuming meat, milk and cheese. A 2005 paper examined the link between breast, ovarian and corpus uteri cancers and diet. Food intake was obtained from the Food and Agriculture Organization for the years 1961-1997 for 40 countries. Cancer statistics were obtained from national registries for the years 1993-1997. It found significant and substantial correlations. 8
- Meat was most closely correlated with the breast cancer incidence (r=0.827), followed by milk (r=0.817) and cheese (r=.0.751)
- Milk was most closely correlated with the incidence of ovarian cancer (r=0.779), followed by animal fats (r=0.717) and cheese (r=0.697).
- Milk was most closely correlated with corpus uteri cancer (r = 0.814), followed by cheese (0.787).
r is the correlation coefficient which is a number between -1 and 1. A correlation coefficient of 0.7 or greater is often considered a strong correlation.
A 2001 paper, discusses a method of reducing sex hormones through a comprehensive change in diet. The study period was 4.5 months. 9
The suggested intervention diet was based on Mediterranean vegetarian and macrobiotic recipes. The dietary recommendations were:
- meat, eggs, and dairy products should not be eaten more than once a week
- consumption of refined carbohydrates (sucrose, white bread, refined flour), be substituted for whole-grain cereal products
- using fruit or fermented cereal
- at least one portion of a soy product (soy milk, miso soup, tofu, tempeh, or soy beans) every day
- 1-kg loaf of bread made from whole wheat flour and 8% flax seed (half whole seeds and half milled), occasionally mixed with oats or rye which was provided
- a free pack of other recommended products that are not a normal part of the northern Italian diet was provided
- consumption of soy products, other legumes, whole-grain cereals, flax and other seeds, seaweed, berries, cabbage family vegetables, and other vegetables
It is much more informative to compare the changes of the participants over the study period instead of comparing them to the control group.
| Criteria | Units | Mean at Start | Mean at End | Change | % Change |
|---|---|---|---|---|---|
| Weight | kg | 67.17 | 63.08 | -4.11 | -0.06 |
| BMI | kg/(m•m) | 26.88 | 25.26 | -1.62 | -0.06 |
| Sex Hormone Binding Globulin (SHBG) | mmol/L | 36.03 | 45.10 | 9.07 | 25.2 |
| Testoserone | pmol/L | 1.42 | 1.14 | -0.28 | -19.5 |
| Estrodiol | nmol/L | 31.64 | 25.95 | -5.69 | -18.0 |
A 1990 paper stated, 10
The 17% reduction in estrodiol is a significant reduction as is the reduction in weight and testosterone. Sex hormone binding globulin (SHBG) was increased 25%. SHBG inhibits the function of sex hormones so the bio-availability of these hormones is influenced by SHBG. All of these changes occurred over a period of 4.5 months.
A whole-food, plant-based diet shows even a greater impact.
The control group also improved their results to a lesser extent.
A short-term study of 17-27 days examined the effects of a low-fat (less than 10%), high-fibre (35-45g per day) diet on estradiol levels. 11
The average fat consumption of the US diet is 33% and the average fibre consumption is 10g per day. The recommendation is 25-30g per day. 12
Serum estradiol fell from an average 66.4 pmol/L to 34.5 pmol/L – a reduction of 48% in a period of 3-4 weeks.
Milk and Breast Cancer
A study that included 52,795 adult women over the course of seven years showed a significant increase in breast cancer risk from drinking 8 ounces (1 250ml cup) of cow’s milk. Participants were from the Adventist Health Study-2. Adventists follow a vegetarian diet and tend to consume significantly more soy than the average American. At the conclusion of the study, 1,057 participants had developed breast cancer. 13
Women who drank 8 ounces of cow’s milk per day increased their risk of breast cancer by 50 percent and those who consumed two to three glasses of cow’s milk increased their risk by up to 80 percent compared to the women who did not drink any dairy milk.
Insulin-like Growth Factor-1 (IGF-1) and Cancers
Insulin-like growth factor (IGF-1) plays a role in cell division (cell proliferation) and inhibits cell death. This applies to tumors as well as normal cells. As a result, IGF-1 is significantly implicated in the development of cancers. 14
The EPIC study (European Prospective Investigation into Cancer and Nutrition) has more than 500,000 participants from 10 European countries. It commenced in 1993.
One research finding showed that for each standard deviation increase in total protein, dairy protein and calcium intake was associated with an increase in IGF-1 concentration of 2.5%, 2.4%, and 3.3%. The standard deviation is a measure of the variability of the data. A small standard deviation means that the data values are clustered around the mean whilst a large standard deviation means the data values are more widely dispersed. 15
A 2002 paper compared IGF-1 concentrations in three populations of women: non-vegetarians, lacto-ovo-vegetarian (includes milk and eggs,) and vegans. Data was obtained from participants in the Oxford component of the EPIC study. 16
Vegans had a 13% lower IGF-1 concentrations than both the non-vegetarians and the lacto-ovo-vegetarian. Giving up meat, fish, eggs and dairy did not make an impact on the IGF-1 values.
A 2006 study over a 2 week period women where placed on a low-fat (10-15% of energy), high-fbre diet and attended daily exercise classes for 2 weeks. Alcohol, cigarettes or caffeine were not permitted. Serum estradiol was reduced 37% and IGF-1 was reduced 19% – in just 2 weeks. The paper stated that other studies have shown alcohol intake of approximately one drink per day was associated with an increase in breast cancer risk. 17
Tamoxifen is an estrogen antagonist (or anti-estrogen) drug. Some side effects include “excesses of endometrial cancer, pulmonary embolism, stroke, deep vein thrombosis, and cataracts“. 18
Yes – tamoxifen was associated with a 3.4 times increase in endometrial cancer rates and nearly a two times increase in thromboembolic events.
In comparison, one diet described above reduced serum estradiol by 48% over a period of 3-4 weeks. Another study showed a reduction in serum estradiol of 37% in 2 weeks. The only side effects are the reduction of many other “diseases of affluence“.
If diet is a deeply implicated in the cancer process as the above evidence suggests, then it makes no sense to hope that research, obtained through massive amounts of funding, will find an answer that is more attuned to society’s dietary preferences – and will not make any impact on corporate profits.
Breast Cancer Statistics
Breast cancer was the second most commonly diagnosed cancer in Australia in 2021. It is estimated that it will remain the second most commonly diagnosed cancer in 2025. 20
Prostate cancer is the most commonly diagnosed cancer followed by breast cancer, melanoma, colorectal (bowel), and lung cancer.
In 2025, it is estimated that the risk of being diagnosed with breast cancer by the age of 85 is 1 in 833 (or 0.1%) for males and 1 in 8 (or 12%) for females.
In 2017–2021, individuals diagnosed with breast cancer had a 93% chance (87% for males and 93% for females) of surviving for five years compared to their counterparts in the general Australian population. Between 1987–1991 and 2017–2021, five-year relative survival for breast cancer improved from 75% to 93%.
As shown below, this is misleading, as a result of “lead time bias“.In 2021, there were 26469 new cases of prostate cancer diagnosed in Australia. In 2025, it is estimated that a male has a 1 in 5 (or 19%) risk of being diagnosed with prostate cancer by the age of 85.
Peter Gøtzsche is a Danish physician and medical researcher. He is a former leader of the Nordic Cochrane Center in Copenhagen, Denmark. He is a co-founder of the Cochrane Collaboration.
Peter C. Gøtzsche, a Danish physician and former director of the Nordic Cochrane Centre, is a prominent critic of mass mammography screening and PSA testing arguing that it causes significant harm through overdiagnosis and does not significantly reduce breast or prostated cancer mortality. His research, along with colleagues like Karsten Juhl Jørgensen, contends that the benefits of screening have been overstated and that the harms—such as unnecessary treatment for cancers that would never have caused symptoms—outweigh the benefits.
Mammaograms and PSA (Prostate Specific Antigen) tests detect the presence of cancer some 10-15 years after cancer first appears. The goal MUST be to prevent cancer from happening in the first place.
He wrote a book Mammogrqphy Screening: Truth, Lies and Controversy. 21 ~ 22 ~ 23
Gøtzsche recommends that,
The apparent increase in breast cancer and prostate cancer survival times comes not from better treatment or earlier detection. You die the same day. You lived longer knowing that you are sick. This is a result of “lead time bias“.
Walter Willet, the famed Harvard epidemiologist and former director of the Nurses’ Study stated in a New York Times interview:
Eric Rimm, another researcher from the Harvard School of Public Health, stated:
The recipes also includes Pulled Pork Burgers and Lamb Samosas for the BBQ. In addition to the problems with consuming processed meat, high-temperature cooking introduces additional dangers. Even the smoke from BBQs or living nearby a restaurant can cause health problems. If you are pregnant, it is advisable to stay clear of BBQ smoke. Airborne products from frying hamburgers, bacon and soybean burgers were tested for mutagenicity (the ability to change DNA).
The fumes generated by frying pork and beef were mutagenic but the soy burgers were not. Well-cooked bacon was 8 times more mutagenic than hamburgers and 350 times more mutagenic than the soy burgers 27.
Additional Reading
Wise Nutrition Coaching
Introduction
About Richard Harding
Professor Truswell – Biography
Dan Repacholi
Breast, Endometrium and Ovarian Cancers
Antimicrobial Resistance, Antibiotics and Endometriosis
Last updated on Monday 13 July 2026 at 17:21 by administrators
Post Type: postFootnotes
- Brown, M. S. (2006) Academy of Achievement – Michael Brown.
- Campbell, T. C. & Campbell, T. M. (2016) The China Study. Revised and Expanded Edition. Dallas, Texas: BenBella Books.
- Campbell, T. C. & Campbell, T. M. (2016) The China Study. Revised and Expanded Edition. Dallas, Texas: BenBella Books.
- World Life Expectancy (n.d.) World Life Expectancy – Statistics [online]. Available from: http://www.worldlifeexpectancy.com/Opens in a new window.
- Henderson, B. E. et al. (1982) Endogenous Hormones as a Major Factor in Human Cancer. Hormones and Cancer. 42 (8), 3232-3236.
- Persson, I. (2000) Estrogens in the causation of breast, endometrial and ovarian cancers — evidence and hypotheses from epidemiological findings. The Journal of Steroid Biochemistry and Molecular Biology. 74 (5), 357–364.
- The Endogenous Hormones and Breast Cancer Collaborative Group (2002) Endogenous Sex Hormones and Breast Cancer in Postmenopausal Women: Reanalysis of Nine Prospective Studies. Journal of the National Cancer Institute. 94 (8), 606–616.
- Ganmaa, D. & Sato, A. (2005) The possible role of female sex hormones in milk from pregnant cows in the development of breast, ovarian and corpus uteri cancers. Medical Hypotheses. 65 (6), 1028–1037.
- Berrino, F. et al. (2001) Reducing Bioavailable Sex Hormones through a Comprehensive Change in Diet: the Diet and Androgens (DIANA) Randomized Trial. Cancer Epidemiology, Biomarkers & Prevention. 10 (1), 10.
- Prentice, R. et al. (1990) Dietary fat reduction and plasma estradiol concentration in healthy postmenopausal women. Journal of the National Cancer Institute. 82 (2), 129–134.
- Heber, D. et al. (1991) Reduction of serum estradiol in postmenopausal women given free access to low-fat high-carbohydrate diet. Nutrition (Burbank, Los Angeles County, Calif.). 7 (2), 137–139.
- U.S. Department of Agriculture (2014) What We Eat in America, NHANES 2011-2012 Tables 41-46.
- Fraser, G. E. et al. (2020) Dairy, soy, and risk of breast cancer: those confounded milks. International Journal of Epidemiology. 49 (5), 1526–1537.
- Endogenous Hormones and Breast Cancer Collaborative Group (2010) Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies. The Lancet Oncology. 11 (6), 530–542.
- Crowe, F. L. et al. (2009) The Association between Diet and Serum Concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology Biomarkers & Prevention. 18 (5), 1333–1340.
- Allen, N. E. et al. (2002) The Associations of Diet with Serum Insulin-like Growth Factor I and Its Main Binding Proteins in 292 Women Meat-Eaters, Vegetarians, and Vegans. Cancer Epidemiology, Biomarkers & Prevention. 11 (11), 1441–1448.
- Barnard, R. J. et al. (2006) Effects of a Low-Fat, High-Fiber Diet and Exercise Program on Breast Cancer Risk Factors In Vivo and Tumor CelI Growth and Apoptosis In Vitro. Nutrition and Cancer. 55 (1), 28–34.
- Freedman, A. N. et al. (2003) Estimates of the Number of U.S. Women Who Could Benefit From Tamoxifen for Breast Cancer Chemoprevention. JNCI Journal of the National Cancer Institute. 95 (7), 526–532.
- Cuzick, J. et al. (2003) Overview of the main outcomes in breast-cancer prevention trials. The Lancet. 361 (9354), 296–300.
- Cancer Australia (2026) Breast cancer in Australia statistics. Available from: https://www.canceraustralia.gov.au/cancer-types/breast-cancer/breast-cancer-australia-statistics.
- Gotzsche, P. (2012). Mammography Screening: Truth, Lies and Controversy. Routledge.
- Mcstrother. (2011). A diagram explaining lead time bias for cancer diagnosis [Graphic]. https://commons.wikimedia.org/wiki/File:Lead_time_bias.svg
- McDougall, J., & Gotzsche, P. (Hosts). (2012, May). Peter Gotzsche, MD: Director of The Nordic Cochrane Centre: Part 1 [Broadcast] https://www.drmcdougall.com/education/lectures/peter-gotzsche-01/#arve-youtube-pacac9p_gsq
- Kolata, G. (1990) Animal Fat is Tied to Colon Cancer – New York Times [online]. Available from: http://www.nytimes.com/1990/12/13/us/animal-fat-is-tied-to-colon-cancer.html (Accessed 28 January 2017).
- Fox, M. (2002) Trans-fat increase cholesterol levels [online]. Available from: http://jawawa.id/index.php/newsitem/trans-fat-increase-cholesterol-levels-1447893297 (Accessed 29 March 2017).
- Bouvard, V. et al. (2015) Carcinogenicity of consumption of red and processed meat International Agency for Research on Cancer Monograph Working Group (WHO) (ed.). The Lancet Oncology. 16 (16), 1599–1600
- Thiebaud, H. et al. (1995) Airborne mutagens produced by frying beef, pork and a soy-based food. Food and Chemical Toxicology. 33 (10), 821–828.





