How do Your Genes Affect Obesity and Diabetes Supplement

A popular area of research is to determine genetic causes of obesity, diabetes, heart disease, autoimmune disease, depression and any other illness or condition that is plaguing our society. Proposed genetic solutions will result in expensive and profit-driven procedures that do not solve the primary cause of the problem.

This area of research ignores the fact that often our genetic code does not determine health outcomes and it will not solve the problems of our society’s rapidly failing health.

Frequently the problem is not that complicated.

An allele is one of two or more versions of a gene. An individual inherits two alleles for each gene, one from each parent.

The most familiar alleles relates to those that determine the ABO blood groups. The ABO blood groups are controlled by a gene that has 6 alleles (O, A, B) – 3 from each parent. Each person can have a gene consisting of the alleles OO, OA, OB, AA, BB or AB. This results in the blood groups O, A, B, A, B, AB since A and B alleles are dominant over the recessive O.

Below are the supplementary data bases associated with the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) is a clinical trial.

The following table shows the baseline values at the start of the study and the changes after the study was completed at 12 months.

CriteriaUnitsLow-fat dietLow-carb diet
Baseline12 month
% ChangeBaseline12 month
% Change
BMIkg/(m * m)33.4-1.75-5.233.3-2.07-6.3
Blood pressure
Fasting glucosemmol/L5.5-0.2-3.65.5-0.1-1.8
Fasting insulinpmol/L110-18-16.4108-16-14.8

The following table shows how the authors grouped the genotypes into the low-fat genotype and low-carbohydrate genotype based on variants to the alleles. The variants are indicated in bold. C’ is pronounced as C prime.

G > A
C > G
C > G
Low Fat Genotype
Low fat1GA'C'C'CC14
Low fat2GA'C'C'CG14
Low fat3GA'C'C'GG4
Low fat4A'AC'C'CC4
Low fat5A'AC'C'CG3
Low Carbohydrate Genotype
Low carb6GACG'CG'6
Low carb7GGCG'CG'5
Low carb8GGCG'GG'1
Low carb9AACG'CG'1
Low carb10GACG'GG'1
Low carb11GGCCCG'19
Low carb12GGCG'CC4
Low carb13GACG'CC3
Low carb14GGCCGG'3
No Genotype

The following table shows the participants with metabolic syndrome at baseline (the start of the study) and the number of participants in the each of genotype groups for the 2 diets.

CriteriaUnitsLow-fat dietLow-carb diet
Metabolic syndrome%34.832.9
Genotype - Low-fat%42.637.5
Genotype - Low-carb%27.231.9
Genotype - None%23.025.0

The following table shows the change in the metabolic syndrome status after 12 months, for the 2 diets.

CriteriaAt startAfter 12
Metabolic syndromeYesNo11.8%11.8%
Metabolic syndromeYesYes12.8%11.8%
Metabolic syndromeNoNo42.0%45.1%
Metabolic syndromeNoYes4.3%3.6%

Last two columns indicate the percentage of people that meet the conditions of the first three columns after 12 months

  • Only 12% of the participants were able to overcome their metabolic syndrome after 12 months on either of the two diets
  • 12% of the participants were unable to overcome their metabolic syndrome after 12 months on either of the two diets
  • 4.3% of the participants on the Low-fat diet and 3.6% on the Low-carb diet managed to acquire their metabolic syndrome condition after 12 months

Last updated on Monday 20 November 2023 at 16:29 by administrators

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